20 Surprising Health Benefits of Lactoferrin

Lactoferrin is a naturally occurring protein that is found in milk and bodily fluids. It is a potent anti-microbial and modulator of the immune system. Several studies have shown that natural lactoferrin has many important roles.

1) Lactoferrin has Antioxidant Properties

Because iron can cause oxidative stress, lactoferrin can reduce oxidative stress by binding and removing iron, which prevents cell damage or cell death. Lactoferrin supplementation can support the immune system as an antioxidant.

2) Lactoferrin Modulates the Immune System

There are lactoferrin receptors on many immune cells, so lactoferrin directly affects how these cells function.


In infants lactoferrin is crucial to the development of natural immune system function to prevent infection.

In mice treated with chemotherapy, treatment with lactoferrin post chemotherapy accelerated the reconstitution of the immune system, reducing the chances for infection following chemotherapy treatment.

In mice suffering from colitis-associated colorectal dysplasia, treatment with lactoferrin reduced their overall deficiency and also reduced the symptoms and inflammation caused by the dysplasia.

3) Lactoferrin Protects Against Inflammation

Although the direct mechanism has not been established yet, lactoferrin is still shown to be effective in preventing inflammation in humans.

Lactoferrin has anti-inflammatory properties when interacting with the immune system against the Epstein-Barr virus, reducing inflammation by inhibiting the activation of TLR2 and TLR9 in the virus DNA.

Lactoferrin in the amniotic fluid is an important component to reducing fetal inflammation in pregnant women through reducing IL-6 levels and reducing infection causing the inflammation.

4) Lactoferrin Helps with Allergies and Asthma

Lactoferrin helps reduce airway inflammation in a mouse asthma model. Lactoferrin blocks histamine release from colon mast cel


Antimicrobial Benefits:

5) Lactoferrin Helps with Bacterial Infections

Lactoferrin helps stop the activity of bacteria. Most bacteria need iron to function, and lactoferrin can stop bacteria from taking up iron in the human body.

In addition to this, it can block bacteria’s carbohydrate metabolism, destabilize their cell walls, or interact with lysozymes in milk to stop bacteria.

In animals with bacterial LPS toxicity, injecting them with lactoferrin reduces many symptoms of toxicity, and reduce risks of death from LPS toxicity by five-fold.

6) Lactoferrin Stops Viruses